3α-Hinokiol with Antitumor Activity from Juniperus Przewals | 94346

Журнал биологии и современного мира

ISSN - 2322-3308


3?-Hinokiol with Antitumor Activity from Juniperus Przewalskii

Huan Zhang and Jieshi Tang

Bioassay-guided fractionation of a methanol extract of the seeds of Juniperus przewalskii Komarov led to the isolation of one diterpene (3α-hinokiol). The structure was determined by means of 1D and 2D NMR spectroscopy, resulting in complete and unambiguous 1H and 13C NMR chemical shift assignments. This compound was evaluated for antiproliferative activities, and was demonstrated to exert significant cell growth inhibitory activity against human ovarian cancer (HO-8910) cells.