A Potential Clinical Index for Parkinson's Disease Using Hum | 96211

Журнал рассеянного склероза

ISSN - 2376-0389


A Potential Clinical Index for Parkinson's Disease Using Human Brain Magnetic Resonance Imaging

Adam Hoffman

Motor dysfunction brought on by substantia nigra functional decline is a hallmark of Parkinson's disease. In patients with Parkinson's disease, decreased putamen volume (also known as putamen atrophy) may be a significant clinical signal of motor dysfunction and neurological symptoms such autonomic dysfunction. On 31 highresolution T2-weighted magnetic resonance images from 19 healthy subjects (age: 75.1 7.85 years; eleven men, eight women) and 30 such pictures from 16 Parkinson's disease patients (age: 80.3 7.30 years), we devised and used a new evaluation approach for putamen volume quantification. An expression for putamen atrophy based on thalamic ratio was used. Using the Wilcoxon rank-sum test, the collected results were utilised to evaluate differences between the groups. The intraclass correlation coefficient demonstrated that this method's validity and intra-rater reliability were both sufficient. The putamen mean change ratio in the Parkinson's disease group was substantially lower (0.633) than that in the control group (0.719), indicating that putamen atrophy may be recognised on two-dimensional pictures. The assessment technique described in this study may be used as a clinical evaluation index for Parkinson's disease and may signal the emergence of motor dysfunction and cognitive deterioration.