Over the past three decades, obesity has become more commonplace around the world. The goal of global anti-obesity efforts is to reduce the progression of obesity through food and lifestyle changes. Due to the potential of natural products to combat obesity, research in the subject of nutrition has recently attracted a great deal of interest. Yerba mate (Ilex paraguariensis) has been deemed a top candidate in numerous investigations. In this review, we assessed the effect of yerba mate on inflammation associated with obesity and obesity itself. Yeerba mate decreases adipocyte differentiation, lipid buildup, and inflammation, according to cell research. Yerba mate regulates the signalling pathways that control adipogenesis, antioxidant, anti-inflammatory, and insulin signalling responses, according to animal research.