Nyityasmono Tri Nugroho
Background AAA is a degenerative vascular disease. Predominant
risk factors are smoking, male, family history
of AAA, and CAD. Reports indicate that two proteins
are significantly up- regulated in the aortic wall of AAA,
sortilin-1 responsibles for circulating lipoprotein and
interleukin 6 (IL-6) a pro-inflammatory interleukin. An
SNP of sort1 rs599839 A>G in vicinity of gene encoding
sortilin 1 and il6r rs2228145 A>C might play a significant
role in the development of AAA. This study aims
to identify the predictive power of those SNPs for the
personalized risk assessment for developing AAA in the
Germany population. Furthermore, with the determination
of the single nucleotide polymorphism of selected
gene, will detect the probability of AAA in the future.