Ewe Jin Koh, Shu Hui Ng, Ee Ling Lai
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is an uncommon disease and occurs more frequently in older adults. It is characterized by symmetrical distal synovitis, pitting edema of the hands and feet, with negative rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP). An association with rheumatological diseases, malignancies - either solid organ tumor or hematological malignancies - and benign conditions are well-reported. We describe a young lady who was diagnosed with RS3PE, and who had an incidental finding of benign left ovarian endometriotic cyst. She responded well to a short course of low dose prednisolone with no recurrence of symptoms after surgical removal of the ovarian endometriotic cyst, suggestive of a possible association of RS3PE and benign gynaecological tumour.