Ultra-low noise organic based devices to record bioelectrica | 80099

Международный журнал инновационных исследований в области науки, техники и технологий


Ultra-low noise organic based devices to record bioelectrical signals in non-excitable cell populations: Applications in anticancer drug screening platforms

Ana L. Mestre, Rute .C. Felix, Maria C. R. Medeiros, Deborah M. Power and Henrique Leonel Gomes

In contrast with the extensive research on devices that explore the neuron-neuron communication, the electronic technology to measure the long-range communication in non-electrogenic (or non-nervous) types of cells is still in its infancy. Non-electrogenic cells generate weak signals (a few micro-volts) with frequencies below 1 Hz. Designing low noise devices in a millihertz frequency range is extremely challenging due to the intrinsic thermal and 1/f type noise generated by the sensing electrode. Our group has pioneered this research in this area [1]–[3] and recently we developed devices with extremely low electrical noise[4]. These novel devices canare capable to detect the faint electrical fluctuations generated by the cooperative activity of non-electrogenic cells. The capacity of devices is capability to measure non-electrogenic cells was achieved by fabricating them devices using an inkjet-printed conducting polymer, the poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS). This soft and micro-fibrillar material enhances the effective area of the electrical double-layers formed between the electrolyte and the sensing surface. Furthermore, the PEDOT: PSS device is flexible, soft and biocompatible